Alternate Aggregation Pathways of the Alzheimer β-Amyloid Peptide
نویسندگان
چکیده
منابع مشابه
Monitoring Alzheimer Amyloid Peptide Aggregation by EPR
Plaques containing the aggregated beta-Amyloid (Abeta) peptide in the brain are the main indicators of Alzheimer's disease. Fibrils, the building blocks of plaques, can also be produced in vitro and consist of a regular arrangement of the peptide. The initial steps of fibril formation are not well understood and could involve smaller aggregates (oligomers) of Abeta. Such oligomers have even bee...
متن کاملHigh-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide
Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease (AD). We describe the engineering of cognate Anticalins as a novel type of neutralizing protein reagent based on the human lipocalin scaffold. Phage display sele...
متن کاملInhibition of Alzheimer amyloid β aggregation by polyvalent trehalose.
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by ...
متن کاملEffect of Metals on Kinetic Pathways of Amyloid-β Aggregation
Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimer's disease through a variety of mechanisms including increased amyloid-β affinity and redox effects. Recent reports have demonstrated that the amyloid-β monomer does not necessarily travel through a definitive intermediary en-route to a stable amyloid fibril structure. Rather, amyloid-β misfolding may fo...
متن کاملAmyloid- in Alzheimer Disease: The Null versus the Alternate Hypotheses
For nearly 20 years, the primary focus for researchers studying Alzheimer disease has been centered on amyloid, such that the amyloid cascade hypothesis has become the “null hypothesis.” Indeed, amyloidis, by the current definition of the disease, an obligate player in pathophysiology, is toxic to neurons in vitro, and, perhaps most compelling, is increased by all of the human genetic influence...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m005698200